GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs516946 | 1 | rs516946 | chr8:41519248 | ANK1 | chr8:41510745-41754280:- | -0.23 | -4.71 | 3.19E-6 | Type 2 diabetes |
| THCA | cis | rs7116495 | 1 | rs517837 | chr11:71802359 | FAM86C | chr11:71498557-71512276:+ | 0.32 | 3.97 | 8.36E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7116495 | 1 | rs520025 | chr11:71562832 | FAM86C | chr11:71498557-71512276:+ | -0.37 | -4.34 | 1.73E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs5219 | 1 | rs5219 | chr11:17409572 | DKFZp686O24166 | chr11:17373317-17398869:+ | 0.12 | 3.59 | 0.000366 | Type 2 diabetes |
| THCA | cis | rs477692 | 1 | rs522891 | chr10:131430916 | MGMT | chr10:131265454-131565783:+ | -0.38 | -11.33 | 1.55E-26 | Response to temozolomide |
| THCA | cis | rs523340 | 1 | rs523340 | chr9:111854246 | C9orf5 | chr9:111777416-111882225:- | -0.19 | -3.55 | 0.000424 | Information processing speed |
| THCA | cis | rs683250 | 1 | rs523494 | chr11:83312379 | CCDC90B | chr11:82972506-82997414:- | 0.17 | 3.89 | 0.000116 | Subcortical brain region volumes |
| THCA | cis | rs525592 | 1 | rs525592 | chr11:68195104 | LOC645332 | chr11:67559240-67572807:- | 0.17 | 3.76 | 0.000195 | Bone mineral density |
| THCA | cis | rs515910 | 1 | rs527154 | chr10:105943683 | C10orf79 | chr10:105889647-105992120:- | 0.25 | 8.06 | 6.05E-15 | Attention deficit hyperactivity disorder |
| THCA | cis | rs494562 | 1 | rs527670 | chr6:86115779 | NT5E | chr6:86159302-86205496:+ | 0.23 | 3.51 | 0.000492 | Blood metabolite levels;Metabolic traits |
| THCA | cis | rs477692 | 1 | rs530466 | chr10:131427717 | MGMT | chr10:131265454-131565783:+ | 0.39 | 11.91 | 7.79E-29 | Response to temozolomide |
| THCA | cis | rs7116495 | 1 | rs531326 | chr11:71570656 | FAM86C | chr11:71498557-71512276:+ | -0.36 | -4.43 | 1.19E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs477692 | 1 | rs531572 | chr10:131427569 | MGMT | chr10:131265454-131565783:+ | -0.38 | -11.84 | 1.56E-28 | Response to temozolomide |
| THCA | cis | rs531676 | 1 | rs531676 | chr10:99637578 | CRTAC1 | chr10:99624758-99790585:- | 0.19 | 3.47 | 0.000577 | Metabolic syndrome |
| THCA | cis | rs1077514 | 1 | rs534417 | chr1:23784965 | ASAP3 | chr1:23755056-23811057:- | 0.31 | 5.04 | 6.62E-7 | Cholesterol, total |